In this review, we cite over 350 URLs that are useful for SB-VLS projects and essentially free for academic groups. A myriad of free applications and services facilitating the drug discovery process have been posted on the Web. Virtual (or in silico) ligand screening based on the three-dimensional structure of macromolecular targets (SB-VLS) is firmly established as an important approach to identify chemical entities that have a high likelihood of binding to a target molecule to elicit desired biological responses. This, coupled with the huge number of small non-peptide potential drug candidates easily available (over 7 million compounds), highlight the need of using computer-aided techniques for the efficient identification and optimization of novel hit compounds. The phone sits well in the hand but the cable's length could be longer.In today's research environment, a wealth of experimental/theoretical structural data is available and the number of therapeutically relevant macromolecular structures is growing rapidly. The phone's unattractive design is not helped by the cheap buttons which feel like they will wear out in less than a month's use. The small LCD with blue backlight is comparable with other phones on the market but in general is very poor. At 140g the phone is relatively heavy given its lack of features. FeaturesĪt only AU$69.95 we were not expecting much from the 225IPC so it was no surprise that the phone's features are quite limited. With the Doro we had no issues with either Windows or Mac OS.

Other manufacturers have had compatibility issues with other platforms even if the VoIP software is working. Installation is relatively easy and works well with both Windows XP/2000 and Mac OS9/X. This can become rather tedious especially when dialing quickly - incorrect dialing can become problematic.

Buttons are well placed but had to be pressed quite firmly for a response. The attached USB cable is long and has a standard curled wire. The 225IPC is a slim-line phone with a contoured surface available in several bright colours as well as standard black.

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